The PRI Research Collection contains more than seven million specimens, making it among the ten largest paleontological collections in the United States. Most of the collection consists of invertebrate fossils, with major strengths in Cenozoic marine mollusks of the Western Hemisphere, Cretaceous mollusks from Seymour Island, Antarctica, and Paleozoic marine invertebrates from New York State. The collection also includes significant collections of Cenozoic benthic foraminifera of the U.S. Coastal Plain and Caribbean, Pleistocene vertebrates of New York State (particularly mastodons), and all non-botanical fossils and Recent mollusks formerly housed at Cornell University. PRI's collection of Type and Figured specimens (also one of the nation's ten largest) includes more than 16,000 specimens. Over the past decade, PRI has also acquired major collections from other institutions, including Dartmouth College and Syracuse University.

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